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This is an MRI liver study, showing multiple, well defined focal hepatic lesions scattered throughout both lobes of the liver – they appear slightly hyperintense on T2 compared to normal liver parenchyma.
The lesions are slightly hyper-enhancing on the portal venous phase post contrast series, and show greater retention of contrast on the delayed series. The lesions show greater retention of the hepatocyte specific contrast agent on the hepato-biliary phase than background liver parenchyma; they also show non-enhancement of the central area, which represents the fibrous scar. This indicates that the lesions contain functioning hepatocytes.
The findings are characteristic of focal nodular hyperplasia.
I would contact the referring physician and inform of the findings. No further management is required.
Question 1:
Why is administration of a hepatocyte specific contrast agent useful in the diagnosis of FNH?
It is useful to differentiate FNH from other lesions like metastases or primary neoplasms, since these would not contain functioning hepatocytes and therefore would not demonstrate uptake of the contrast agent.
Question 2:
Would biopsy be recommended in this case to confirm the diagnosis?
No. Biopsy is unnecessary since the radiological findings are enough to make a diagnosis, and biopsy risks a false result which may lead to unnecessary surgery.
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